![]() It is worth mentioning that the yolk–shell architecture is a promising candidate for developing drug loading systems compared with the core–shell structure, owing to the unique cavity, large surface area and excellent loading capacity. Moreover, up to now, there have been no reports on the synthesis of CaP-based yolk–shell NPs composed of a CaP shell and a removable AuNR yolk. ![]() However, their materials still have problems that need to be tackled including large particle size, poor biocompatibility and low drug loading capability. Recently, Lu and co-workers prepared yolk–shell periodic mesoporous organosilica nanospheres only for chemo-photothermal therapy of breast cancer. Meanwhile, AuNRs possess photoacoustic (PA) and X-ray computed tomography (CT) imaging capacity, due to the strong near-infrared (NIR) absorption and X-ray opacity. Therefore, it is absolutely imperative to propose a simple synthetic method for fabricating CaP-based multifunctional NPs that possess the capacities of simultaneous dual-mode imaging diagnosis and chemo-photothermal therapy.Īmong numerous photothermal nanomaterials, the optical property of gold nanorod (AuNRs) presented good photothermal therapy (PTT) effect owing to their tunable localized surface plasmon resonance (LSPR) across the NIR region. It should be noted that sole modality imaging or therapy cannot enhance the anticancer efficiency in comparison with multimodal imaging and multiple therapeutic. developed a synthetic route to obtain amphiphilic gelatin–iron oxide core/CaP shell NPs, integrating magnetic resonance imaging and chemotherapy for killing cancer cells. The main strategy turns to synthesize CaP-based multifunctional NPs with the capability of diagnosis and therapeutics. ![]() However, owing to the lack of the theranostic capability, single CaP NPs are difficult to achieve simultaneous imaging and cancer theranostics. Nowadays, calcium phosphate (CaP) NPs have gained increasing attention in anticancer drug delivery because of their excellent biocompatibility and pH-sensitivity, originating from their chemical nature and mimics the inorganic component of biological hard tissues, such as bone and tooth. Multifunctional nanoparticles (NPs) with complementary capacities of multimodal imaging and therapeutic functions have drawn extensive attention in biomedical areas. ![]()
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